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Yi-Xian Qin, Ph.D.
Asst. Professor,
Department of Biomedical Engineering
Funding through the National Space Biomedical Research Institute (NSBRI),
US Army Medical Research, and National Institute of Health (NIH).
Figure 1. Finite element modeling
of a porous coated implant and the interface with bone, examining
the mechanical characteristics of osseointegration. This work
demonstrates the specific mechanical environment which promotes
bony ingrowth, and therefore stabilization, of the implant. |
Figure 2. Bone fluid flow is hypothesized
to play a critical regulatory role in bone remodeling, and is
closely coupled to the dynamic loading conditions of the bone
(e.g., frequency and strain rate). Under identical strain amplitudes,
high frequency mechanical stimuli (30 Hz) creates approximately
a 10-fold increase in fluid flow, as compared to low frequency
loading (0.1 Hz). |
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Research in my lab is focused on the physical mechanisms involved in
the control of tissue growth, healing, and homeostasis, especially bone
adaptation influenced by mechanical environment. And how these mechanisms
can be utilized in the treatment and prevention of disease and injury.
It is clear that bone senses and responds to biomechanical stimuli towards
the achievement and maintenance of a structurally appropriate skeletal
structure. In addition to strain magnitude, bone tissue has the ability
to differentiate between shear and normal strain, cycle number, loading
frequency, and even fluid pressure and its gradients. The interdependent
roles of these mechanical signals are investigated through empiric and
analytic models to provide support for the complex interactive mechanism
of bone remodeling.
My research also focuses on the development of non-invasive scanning
acoustic diagnostic system for tissue quality. The goal of this project
is to develop a new technology, which will lead to a better understand
of the progressive adaptation of bone loss in aging populations and microgravity
environment. The technology will be used for assessing musculoskeletal
complications such as osteoporosis.
IBRP intern will be expected to work in the lab with other graduate and
undergraduate students on a dedicated project which will include hands-on
experiment and data analysis. Computational background, and/or materials
characterization interests, would bring assets to the lab.
Contact Information
email: yi-xian.qin@sunysb.edu
url: http://www.bme.sunysb.edu/bme/people/faculty/y_qin.html
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